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We present for the first time an adjustable liquid-liquid extraction (LLE) device that allows coaxial aqueous-organic extractions with the stable liquid-liquid interface. A helix wire is placed in the extraction tube stabilizes the 3D coaxial flowing immiscible streams, offering operation of the device both at high and at very low flow rates. This significantly enhances the applicability of microfluidic devices to investigate and achieve optimal extraction conditions. In this contribution, we demonstrate the prototype of adjustable pitch liquid-liquid extraction (LLE) device with regard to fluid properties, hydrodynamic and transport phenomena and discuss experimental extraction data. Such comprehensive understanding will in the future facilitate the process optimizations, and thus accelerate the uptake of microfluidic devices in the bioprocessing industry.

This research project includes many disciplines. It establishes visualization technologies from the physical characteristics of liquid flow, and the subsequent engineering design illustrates the multi-scale fluid dynamics of flow inlets and external flow. Additionally, it answers biological questions about somatotopic maps inside the nasal cavity. Interdisciplinary cooperations as such will strengthen and expand new scientific questions.
 

Co-work with Prof. Wang, Prof. Chi at Physics Department of NCHU, Prof. Jeng-Horng Chen at Dept. of Systems & Naval Mechatronic Eng. & Director of NCKU Museum and National Museum of Natural Science 國立自然科學博物館

The concept of Lab-on-Chips, miniaturized fluidics systems, and Biochips contains the use of a fluid to perform analogue or digital operation. The temporal and spatial fluidic driving and control in microfluidic systems usually involves a complex pump, tubing, and connection system. Reducing numbers of external components is crucial for the usage of non-engineering background scientists. In this project, we first demonstrated a novel pump-free device utilizing osmotic pressure to control and modulating fluid flow in microfluidic networks. This research also showed a cell trapping application on biomedical uses.

Microfluidic-based BBB model, to be conceived of this project, has a stable micro-engineered environment so will combine the advantages of the current in vitro models and in vivo models. It will constitute a rapid screening tool for permeability of various nanoparticle candidates, across the neuro-protective BBB without the use of living animals. The delivery properties of therapeutics delivery across the neuroprotective BBB can be obtained.

路殺預警系統

自動化動物辨識

聲光波動物緩速系統
中部友善道路

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AI project initiated by Taiwan’s Directorate General of Highways to detect leopard cats when they near roads and keep them out of harm’s way, reducing roadkills..